Get ready to fire up your taste buds—because this Cajun Salmon and Shrimp recipe is bold, buttery, and downright irresistible. If you’re craving something spicy, savory, and full of Southern soul, this dish brings it all to the table. Juicy Cajun-spiced salmon fillets and tender shrimp, seared to perfection, come together in one pan for a meal that feels fancy but is actually super easy to make.
Whether you’re planning a cozy dinner for two, feeding a hungry family, or meal-prepping for the week, this recipe delivers restaurant-quality flavor in under 30 minutes. Let’s dive in, because this one’s going to steal your heart (and maybe your breath—hello Cajun heat 🔥).
Why You’ll Love This Cajun Salmon and Shrimp Recipe
There’s something magical about Cajun seasoning. It’s smoky, spicy, herby, and savory all at once—and it transforms salmon and shrimp into a total flavor bomb. This dish is:
- One-pan, 30-minute magic
- Low-carb and high-protein (great for keto or Whole30 diets)
- Customizable with spice level, veggies, or sauces
- Perfect for weeknights or special occasions
- Big on flavor, low on fuss
And best of all? It’s just as delicious as it looks.
Ingredients
For the seafood:
- 4 salmon fillets (skin-on or skinless, about 6 oz each)
- ½ lb large shrimp, peeled and deveined
- 2–3 tbsp Cajun seasoning (store-bought or homemade)
- 2 tbsp olive oil or avocado oil
- 1 tbsp butter (for finishing)
- Lemon wedges, for serving
Optional sides or additions:
- Sautéed spinach, asparagus, or zucchini
- Rice, cauliflower rice, or creamy grits
- Garlic butter or Cajun cream sauce (see pro tips below)
Homemade Cajun Seasoning (optional):
Mix together:
- 1 tbsp smoked paprika
- 1 tsp garlic powder
- 1 tsp onion powder
- 1 tsp dried oregano
- ½ tsp thyme
- ½ tsp cayenne pepper (adjust to heat preference)
- 1 tsp salt
- ½ tsp black pepper
Tools You’ll Need
- Cast iron skillet or heavy-bottomed pan
- Tongs or spatula
- Paper towels
- Small bowl (for seasoning mix)
- Lemon squeezer or fork
How to Make Cajun Salmon and Shrimp
Step 1: Prep the seafood
Pat salmon and shrimp dry with paper towels—this helps you get that golden sear. Rub both with olive oil and season generously on all sides with Cajun seasoning.
Let them sit at room temp for about 10 minutes while you prep your pan.
Step 2: Sear the salmon
Heat 1 tablespoon of oil in a large skillet over medium-high heat. Once hot, add salmon skin-side down (if using skin-on). Cook for 4–5 minutes without moving it—this helps get a crispy crust.
Flip and cook another 3–4 minutes until the salmon is cooked through and flakes easily. Remove from the pan and set aside.
Step 3: Cook the shrimp
Add a bit more oil if needed, then toss in the shrimp. Sauté for 2–3 minutes per side, until pink and just cooked. Add 1 tablespoon of butter to the pan and swirl it around to coat the shrimp in that flavorful butter.
Optional: squeeze a bit of fresh lemon juice into the pan to brighten everything up.
Step 4: Bring it all together
Return the salmon to the pan, nestling it among the shrimp. Spoon some of that buttery goodness over the top. Garnish with lemon wedges, chopped parsley, or even a few dashes of hot sauce if you like it extra spicy.
Serving Suggestions
This Cajun Salmon and Shrimp is a total showstopper on its own, but here are a few delicious ways to complete your plate:
- Over creamy grits with garlic butter = Southern comfort at its finest
- With rice or cauliflower rice to soak up all those juicy pan drippings
- On top of a big salad with avocado and a zesty vinaigrette
- Tucked into tacos with slaw and spicy mayo
- Alongside roasted veggies for a lighter, low-carb dinner
And don’t forget a cold drink to cool off that Cajun heat—sparkling water with lime, a cold beer, or a crisp white wine all work beautifully.
Pro Tips for Maximum Flavor
- Don’t overcrowd the pan. Cook in batches if needed for the best sear.
- Adjust the heat. Like it mild? Use less cayenne in your seasoning. Want it spicy? Add a dash of hot sauce or red pepper flakes to the pan.
- Use wild-caught salmon if possible—it has richer flavor and better texture.
- For a creamier version, add a quick Cajun cream sauce: sauté garlic in the pan after cooking, then add ½ cup heavy cream, a splash of broth, and 1 tsp Cajun seasoning. Simmer until thickened, then pour over the salmon and shrimp.
- Want to meal prep? Cook everything and store it in containers with rice and veggies—it reheats like a dream.
Storage & Reheating
To store:
Keep leftovers in an airtight container in the fridge for up to 3 days.
To reheat:
Warm in a skillet over medium-low heat with a splash of water or broth, or microwave on 50% power to avoid overcooking.
Freezing tip:
You can freeze cooked salmon and shrimp, but shrimp may lose a bit of texture. Store in freezer-safe containers for up to 2 months. Thaw in the fridge before reheating.
Frequently Asked Questions
Can I grill the salmon and shrimp instead of pan-searing?
Absolutely! Just brush with oil and season, then grill salmon for 4–5 minutes per side and shrimp for 2–3 minutes per side.
Can I use frozen salmon or shrimp?
Yes—just thaw completely and pat dry before seasoning.
What if I want to add veggies?
Bell peppers, zucchini, or spinach sauté beautifully in the same pan. Just cook them before or after the seafood to keep things crisp and fresh.
Is Cajun seasoning very spicy?
It can be! You can make your own blend to control the heat or buy a mild version at the store.
Final Thoughts
This Cajun Salmon and Shrimp recipe is everything you want in a weeknight meal: easy, flavorful, and packed with protein. With just one pan and a handful of ingredients, you’ll create a dish that tastes like it came from your favorite seafood restaurant.
Whether you’re cooking for someone special, feeding a hungry family, or treating yourself to something bold and delicious, this recipe delivers in every way.
Craving more Cajun flavor? Check out my Cajun Chicken Alfredo or Blackened Shrimp Tacos next!
If you give this recipe a try, drop a comment below or tag me on Instagram—I love seeing your kitchen creations. 💛🍤🐟
Estimated Nutrition (per serving, 1 salmon fillet + shrimp)
Calories: 430 | Protein: 42g | Fat: 26g | Carbs: 2g | Fiber: 0g
(Note: Nutrition may vary depending on sides and portion sizes.)
🔥 Stay spicy, and happy cooking!